Hyperplasia and Cellularity Changes in IGF-1-Overexpressing Skeletal Muscle of Crucian Carp
نویسندگان
چکیده
منابع مشابه
Muscle-specific inactivation of the IGF-I receptor induces compensatory hyperplasia in skeletal muscle.
During the development of skeletal muscle, myoblasts withdraw from the cell cycle and differentiate into myotubes. The insulin-like growth factors IGF-I and IGF-II, through their cognate tyrosine kinase receptor (IGF-I receptor), are known to play a role in this process. After withdrawal of myoblasts from the cell cycle, IGF-I promotes muscle differentiation by inducing the expression or activi...
متن کاملChanges in skeletal muscle cellularity in starved and refed young rats.
1. All food was withdrawn from male weanling rats until a 40% loss of body-weight was attained. Another group of animals was treated similarly and then refed a stock diet until the original body-weight was attained. 2. The body-weight loss caused a significant reduction in the weight of the heart, kidney, liver and epididymal fat pads. Refeeding produced a return to the control weight of the he...
متن کاملConsequences of pig domestication for skeletal muscle growth and cellularity
This study was conducted to investigate the impact of domestication of the pig on various cellular properties of skeletal muscle. For this purpose, samples of semitendinosus (ST), psoas major (PM), and longissimus (LD) muscles of 24 European wild boars (WB; Sus scrofa scrofa) and of 28 domestic pigs (Sus scrofa domestica) of German Landrace (DP) were taken at birth, and at 7 and 20 weeks of age...
متن کاملMaintained cardiac pumping in anoxic crucian carp.
Like most vertebrates, humans die within minutes when deprived of molecular oxygen (anoxia), in part because of cardiac failure. In contrast, some freshwater turtles can survive anoxia for months at low temperatures, but to do so, they drastically suppress cardiac activity and autonomic cardiovascular control. Although Carassius carassius, the crucian carp, shares this anoxia tolerance, we show...
متن کاملSeasonal changes in glycogen content and Na+-K+-ATPase activity in the brain of crucian carp.
Changes in the number of Na+-K+-ATPase alpha-subunits, Na+-K+-ATPase activity and glycogen content of the crucian carp (Carassius carassius) brain were examined to elucidate relative roles of energy demand and supply in adaptation to seasonal anoxia. Fish were collected monthly around the year from the wild for immediate laboratory assays. Equilibrium dissociation constant and Hill coefficient ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Endocrinology
سال: 2014
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2013-1938